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Diabetic foot ulcer is one of the major complications of diabetes mellitus. 15% of patients who have been diagnosed with diabetes are suffer from foot ulcers after 5 to 10 years, nearly 10 to 15% of them are end up with an amputation. 

Medical ozone therapy has been widely used for more than 50 years in western countries like Germany and Italy, and curative effect of medical ozone therapy which is remarkable. Also, it plays an important role in treating diabetic foot and peripheral vascular diseases. 

Extracorporeal Blood Oxygenation and Ozonation (EBOO) is one of the main treatments for diabetic foot. It can improves blood circulation of the feet, increases oxygen contents in ischemic tissues, improves metabolism, lower blood glucose, in order to avoid amputation. Medical ozone has been found to have functions to inhibit the bacteria and promote the wound healing.